Diabeetikon VTI:n esiintyvyys
Lisätietoa aiheesta
18.6.2019
- Tavallisin oireetonta bakteriuriaa aiheuttava bakteeri diabeetikolla on E. coli «Diabeetikkojen ja diabetesta sairastamattomien VTI:n aiheuttajien suhteelliset osuudet ovat samanlaiset. Diabetes ei ole itsenäinen mikrobilääkeresistenssin riskitekijä.»A.
- Oireettomana virtsassa kasvavilla E. coli -bakteereilla ei ole niitä virulenssiominaisuuksia, joita oireisten tulehdusten aiheuttajilla on «Dalal S, Lindsay N, Marrs CF, Zhang L, Harding G, Foxman B. Long term Escherichia coli asymptomatic bacteriuria among women with diabetes. Clin Infect Dis 2009;49:491-7; PMID:19583518 »1.
- Diabetes lisää oireettoman bakteriurian ja oireisten virtsatieinfektioiden riskiä «Dalal S, Lindsay N, Marrs CF, Zhang L, Harding G, Foxman B. Long term Escherichia coli asymptomatic bacteriuria among women with diabetes. Clin Infect Dis 2009;49:491-7; PMID:19583518 »1, «Renko M, Tapanainen P, Tossavainen P ym. Meta-analysis of the significance of asymptomatic bacteriuria in diabetes. Diabetes Care 2011;34:230-5 »2, «Schneeberger C, Holleman F, Geerlings SE. Febrile urinary tract infections: pyelonephritis and urosepsis. Curr Opin Infect Dis 2016;29:80-5 »8, «Fu AZ, Iglay K, Qiu Y ym. Risk characterization for urinary tract infections in subjects with newly diagnosed type 2 diabetes. J Diabetes Complications 2014;28:805-10 »9.
- Oireeton bakteriuria lisää oireisen VTI:n riskiä tyypin 2 diabeetikolla, mutta ei tyypin 1 diabetesta sairastavilla «Geerlings SE, Stolk RP, Camps MJ ym. Risk factors for symptomatic urinary tract infection in women with diabetes. Diabetes Care 2000;23:1737-41 »3, «Geerlings SE, Stolk RP, Camps MJ ym. Consequences of asymptomatic bacteriuria in women with diabetes mellitus. Arch Intern Med 2001;161:1421-7 »4.
- Syyt lisääntyneeseen VTI-alttiuteen ovat osittain epäselvät «Diabetesta sairastavien VTI-alttiuden syyt»1.
- Diabeetikon VTI:hin liittyy enemmän komplikaatioita, kuten munuaistason tulehduksia, intra- tai perirenaalisia absesseja ja sepsiksiä «Nicolle LE, Friesen D, Harding GK ym. Hospitalization for acute pyelonephritis in Manitoba, Canada, during the period from 1989 to 1992; impact of diabetes, pregnancy, and aboriginal origin. Clin Infe»5, «Joshi N, Caputo GM, Weitekamp MR ym. Infections in patients with diabetes mellitus. N Engl J Med 1999;341:1906-12 »6, «Nicolle LE. Urinary tract infections in diabetes. Curr Opin Infect Dis 2005;18:49-53; PMID: 15647700»7.
- Iäkkäillä diabeetikon pyelonefriittiin liittyy useammin bakteremiaa, ja myös kuolleisuus on korkeampi «Kofteridis DP, Papadimitraki E, Mantadakis E ym. Effect of diabetes mellitus on the clinical and microbiological features of hospitalized elderly patients with acute pyelonephritis. J Am Geriatr Soc 2»11.
- Diabeetikko joutuu pyelonefriitin takia sairaalahoitoon useammin kuin diabetesta sairastamaton «Korbel L, Spencer JD. Diabetes mellitus and infection: an evaluation of hospital utilization and management costs in the United States. J Diabetes Complications 2015;29:192-5 »10
- Diabeetikon sairaalahoitoon johtaneen virtsatieinfektion hoitoaika sairaalassa on pitempi kuin vastaavilla potilailla, joilla ei ole diabetesta «Nicolle LE. Urinary tract infections in diabetes. Curr Opin Infect Dis 2005;18:49-53; PMID: 15647700»7, «Kofteridis DP, Papadimitraki E, Mantadakis E ym. Effect of diabetes mellitus on the clinical and microbiological features of hospitalized elderly patients with acute pyelonephritis. J Am Geriatr Soc 2»11.
- Lisätietoa ks. «Diabetesta sairastavien VTI-alttiuden syyt»1.
Kirjallisuutta
- Dalal S, Lindsay N, Marrs CF, Zhang L, Harding G, Foxman B. Long term Escherichia coli asymptomatic bacteriuria among women with diabetes. Clin Infect Dis 2009;49:491-7; PMID:19583518
- Renko M, Tapanainen P, Tossavainen P ym. Meta-analysis of the significance of asymptomatic bacteriuria in diabetes. Diabetes Care 2011;34:230-5 «PMID: 20937688»PubMed
- Geerlings SE, Stolk RP, Camps MJ ym. Risk factors for symptomatic urinary tract infection in women with diabetes. Diabetes Care 2000;23:1737-41 «PMID: 11128343»PubMed
- Geerlings SE, Stolk RP, Camps MJ ym. Consequences of asymptomatic bacteriuria in women with diabetes mellitus. Arch Intern Med 2001;161:1421-7 «PMID: 11386891»PubMed
- Nicolle LE, Friesen D, Harding GK ym. Hospitalization for acute pyelonephritis in Manitoba, Canada, during the period from 1989 to 1992; impact of diabetes, pregnancy, and aboriginal origin. Clin Infect Dis 1996;22:1051-6 «PMID: 8783709»PubMed
- Joshi N, Caputo GM, Weitekamp MR ym. Infections in patients with diabetes mellitus. N Engl J Med 1999;341:1906-12 «PMID: 10601511»PubMed
- Nicolle LE. Urinary tract infections in diabetes. Curr Opin Infect Dis 2005;18:49-53; PMID: 15647700
- Schneeberger C, Holleman F, Geerlings SE. Febrile urinary tract infections: pyelonephritis and urosepsis. Curr Opin Infect Dis 2016;29:80-5 «PMID: 26658652»PubMed
- Fu AZ, Iglay K, Qiu Y ym. Risk characterization for urinary tract infections in subjects with newly diagnosed type 2 diabetes. J Diabetes Complications 2014;28:805-10 «PMID: 25161100»PubMed
- Korbel L, Spencer JD. Diabetes mellitus and infection: an evaluation of hospital utilization and management costs in the United States. J Diabetes Complications 2015;29:192-5 «PMID: 25488325»PubMed
- Kofteridis DP, Papadimitraki E, Mantadakis E ym. Effect of diabetes mellitus on the clinical and microbiological features of hospitalized elderly patients with acute pyelonephritis. J Am Geriatr Soc 2009;57:2125-8 «PMID: 20121956»PubMed