Ulkuksen ja mahasyövän riskitekijät
Lisätietoa aiheesta
10.4.2019
- Ulkustaudin ja mahasyövän riskitekijöitä on lueteltu taulukoissa «Ulkustaudin riskitekijöitä.»1 ja «Mahasyövän riskitekijöitä , , , .»2; «Uemura N, Okamoto S, Yamamoto S ym. Helicobacter pylori infection and the development of gastric cancer. N Engl J Med 2001;345:784-9 »1, «Voutilainen M, Mäntynen T, Färkkilä M ym. Impact of non-steroidal anti-inflammatory drug and aspirin use on the prevalence of dyspepsia and uncomplicated peptic ulcer disease. Scand J Gastroenterol 20»3, «Lassen A, Hallas J, Schaffalitzky de Muckadell OB. Complicated and uncomplicated peptic ulcers in a Danish county 1993-2002: a population-based cohort study. Am J Gastroenterol 2006;101:945-53 »4, «Garrow D, Delegge MH. Risk factors for gastrointestinal ulcer disease in the US population. Dig Dis Sci 2010;55:66-72 »5, «Karttunen T, Kivilaakso E. Mahalaukun kasvaimet. Kirjassa: Gastroenterologia ja hepatologia. Höckerstedt K, Färkkilä M, Kivilaakso E, Pikkarainen P (toim). Kustannus Oy Duodecim 2007:332-3»6, «Sipponen P, Kekki M, Haapakoski J ym. Gastric cancer risk in chronic atrophic gastritis: statistical calculations of cross-sectional data. Int J Cancer 1985;35:173-7 »7.
- Tulehduskipulääkkeiden käyttö lisää ulkusriskin – sekä helikobakteeripositiivisilla että negatiivisilla – 3–5-kertaiseksi «Helicobacter and Cancer Collaborative Group. Gastric cancer and Helicobacter pylori: a combined analysis of 12 case control studies nested within prospective cohorts. Gut 2001;49:347-53 »2, «Papatheodoridis GV, Sougioultzis S, Archimandritis AJ. Effects of Helicobacter pylori and nonsteroidal anti-inflammatory drugs on peptic ulcer disease: a systematic review. Clin Gastroenterol Hepatol »8, «Tielemans MM, Eikendal T, Jansen JB ym. Identification of NSAID users at risk for gastrointestinal complications: a systematic review of current guidelines and consensus agreements. Drug Saf 2010;33:4»9.
- Helikobakteerinegatiivisen dyspepsiapotilaan ulkusriski on vähäinen, ellei hän käytä tulehduskipulääkkeitä «Heikkinen M, Färkkilä M. Long-term outcome of functional dyspepsia: effect of Helicobacter pylori infection. A 6- to 7-year follow-up study. Scand J Gastroenterol 2002;37:905-10 »10, «Voutilainen M, Mäntynen T, Kunnamo I ym. Impact of clinical symptoms and referral volume on endoscopy for detecting peptic ulcer and gastric neoplasms. Scand J Gastroenterol 2003;38:109-13 »11.
- Nuorissa ikäluokissa duodenaaliulkus dyspepsian syynä on käynyt harvinaiseksi helikobakteeri-infektion vähentymisen myötä «Kosunen TU, Aromaa A, Knekt P ym. Helicobacter antibodies in 1973 and 1994 in the adult population of Vammala, Finland. Epidemiol Infect 1997;119:29-34 »20, «Harvey RF, Spence RW, Lane JA ym. Relationship between the birth cohort pattern of Helicobacter pylori infection and the epidemiology of duodenal ulcer. QJM 2002;95:519-25 »21.
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Tulehduskipulääkkeiden käyttöä potilailla, joilla on ulkusriski, käsitellään Kipu Käypä hoito -suosituksen Kipulääkkeen valinta -taulukossa «http://www.terveysportti.fi/xmedia/hoi/hoi50103/Kipulaakkeen_valinta.html»1.
- Pelkkä kortisoni ei lisää merkittävästi ulkusriskiä, mutta yhdessä tulehduskipulääkkeen kanssa käytettäessä erityisesti ulkuskomplikaatioriski kasvaa «Piper JM, Ray WA, Daugherty JR ym. Corticosteroid use and peptic ulcer disease: role of nonsteroidal anti-inflammatory drugs. Ann Intern Med 1991;114:735-40 »12, «Conn HO, Poynard T. Corticosteroids and peptic ulcer: meta-analysis of adverse events during steroid therapy. J Intern Med 1994;236:619-32 »13, «Nielsen GL, Sørensen HT, Mellemkjoer L ym. Risk of hospitalization resulting from upper gastrointestinal bleeding among patients taking corticosteroids: a register-based cohort study. Am J Med 2001;11»14, «Hernández-Díaz S, Rodríguez LA. Steroids and risk of upper gastrointestinal complications. Am J Epidemiol 2001;153:1089-93 »15, «Martínek J, Hlavova K, Zavada F ym. "A surviving myth"--corticosteroids are still considered ulcerogenic by a majority of physicians. Scand J Gastroenterol 2010;45:1156-61 »16.
- SSRI-tyyppinen masennuslääke lisää ulkusriskiä ja varsinkin vuotoriskiä yhdessä tulehduskipulääkkeen kanssa «Dall M, Schaffalitzky de Muckadell OB, Lassen AT ym. There is an association between selective serotonin reuptake inhibitor use and uncomplicated peptic ulcers: a population-based case-control study. »17, «Loke YK, Trivedi AN, Singh S. Meta-analysis: gastrointestinal bleeding due to interaction between selective serotonin uptake inhibitors and non-steroidal anti-inflammatory drugs. Aliment Pharmacol The»18.
- Taulukossa «Ulkustaudin riskitekijöitä.»1 on lueteltu ulkustaudin ja taulukossa «Mahasyövän riskitekijöitä , , , .»2 mahasyövän riskitekijöitä.
Kirjallisuutta
- Uemura N, Okamoto S, Yamamoto S ym. Helicobacter pylori infection and the development of gastric cancer. N Engl J Med 2001;345:784-9 «PMID: 11556297»PubMed
- Helicobacter and Cancer Collaborative Group. Gastric cancer and Helicobacter pylori: a combined analysis of 12 case control studies nested within prospective cohorts. Gut 2001;49:347-53 «PMID: 11511555»PubMed
- Voutilainen M, Mäntynen T, Färkkilä M ym. Impact of non-steroidal anti-inflammatory drug and aspirin use on the prevalence of dyspepsia and uncomplicated peptic ulcer disease. Scand J Gastroenterol 2001;36:817-21 «PMID: 11495076»PubMed
- Lassen A, Hallas J, Schaffalitzky de Muckadell OB. Complicated and uncomplicated peptic ulcers in a Danish county 1993-2002: a population-based cohort study. Am J Gastroenterol 2006;101:945-53 «PMID: 16573778»PubMed
- Garrow D, Delegge MH. Risk factors for gastrointestinal ulcer disease in the US population. Dig Dis Sci 2010;55:66-72 «PMID: 19160043»PubMed
- Karttunen T, Kivilaakso E. Mahalaukun kasvaimet. Kirjassa: Gastroenterologia ja hepatologia. Höckerstedt K, Färkkilä M, Kivilaakso E, Pikkarainen P (toim). Kustannus Oy Duodecim 2007:332-3
- Sipponen P, Kekki M, Haapakoski J ym. Gastric cancer risk in chronic atrophic gastritis: statistical calculations of cross-sectional data. Int J Cancer 1985;35:173-7 «PMID: 3871738»PubMed
- Papatheodoridis GV, Sougioultzis S, Archimandritis AJ. Effects of Helicobacter pylori and nonsteroidal anti-inflammatory drugs on peptic ulcer disease: a systematic review. Clin Gastroenterol Hepatol 2006;4:130-42 «PMID: 16469671»PubMed
- Tielemans MM, Eikendal T, Jansen JB ym. Identification of NSAID users at risk for gastrointestinal complications: a systematic review of current guidelines and consensus agreements. Drug Saf 2010;33:443-53 «PMID: 20486727»PubMed
- Heikkinen M, Färkkilä M. Long-term outcome of functional dyspepsia: effect of Helicobacter pylori infection. A 6- to 7-year follow-up study. Scand J Gastroenterol 2002;37:905-10 «PMID: 12229964»PubMed
- Voutilainen M, Mäntynen T, Kunnamo I ym. Impact of clinical symptoms and referral volume on endoscopy for detecting peptic ulcer and gastric neoplasms. Scand J Gastroenterol 2003;38:109-13 «PMID: 12613446»PubMed
- Piper JM, Ray WA, Daugherty JR ym. Corticosteroid use and peptic ulcer disease: role of nonsteroidal anti-inflammatory drugs. Ann Intern Med 1991;114:735-40 «PMID: 2012355»PubMed
- Conn HO, Poynard T. Corticosteroids and peptic ulcer: meta-analysis of adverse events during steroid therapy. J Intern Med 1994;236:619-32 «PMID: 7989897»PubMed
- Nielsen GL, Sørensen HT, Mellemkjoer L ym. Risk of hospitalization resulting from upper gastrointestinal bleeding among patients taking corticosteroids: a register-based cohort study. Am J Med 2001;111:541-5 «PMID: 11705430»PubMed
- Hernández-Díaz S, Rodríguez LA. Steroids and risk of upper gastrointestinal complications. Am J Epidemiol 2001;153:1089-93 «PMID: 11390328»PubMed
- Martínek J, Hlavova K, Zavada F ym. "A surviving myth"--corticosteroids are still considered ulcerogenic by a majority of physicians. Scand J Gastroenterol 2010;45:1156-61 «PMID: 20569095»PubMed
- Dall M, Schaffalitzky de Muckadell OB, Lassen AT ym. There is an association between selective serotonin reuptake inhibitor use and uncomplicated peptic ulcers: a population-based case-control study. Aliment Pharmacol Ther 2010;32:1383-91 «PMID: 21050241»PubMed
- Loke YK, Trivedi AN, Singh S. Meta-analysis: gastrointestinal bleeding due to interaction between selective serotonin uptake inhibitors and non-steroidal anti-inflammatory drugs. Aliment Pharmacol Ther 2008;27:31-40 «PMID: 17919277»PubMed
- Ahsberg K, Ye W, Lu Y ym. Hospitalisation of and mortality from bleeding peptic ulcer in Sweden: a nationwide time-trend analysis. Aliment Pharmacol Ther 2011;33:578-84 «PMID: 21210831»PubMed
- Kosunen TU, Aromaa A, Knekt P ym. Helicobacter antibodies in 1973 and 1994 in the adult population of Vammala, Finland. Epidemiol Infect 1997;119:29-34 «PMID: 9287940»PubMed
- Harvey RF, Spence RW, Lane JA ym. Relationship between the birth cohort pattern of Helicobacter pylori infection and the epidemiology of duodenal ulcer. QJM 2002;95:519-25 «PMID: 12145391»PubMed